Lin Lab Publishes Paper Describing TEQUILA-seq in Nature Communications
A research article published today in Nature Communications by the Lin Lab describes TEQUILA-seq, a versatile and low-cost method for targeted long-read RNA sequencing utilizing isothermally linear-amplified capture probes. TEQUILA-seq reduces the per-reaction cost of targeted capture by 2-3 orders of magnitude, as compared to a standard commercial solution. TEQUILA-seq can be broadly used for targeted sequencing of full-length transcripts in diverse biomedical research settings, such as cancer.
Lin Lab Receives CHOP 2023 Omics Maximizing Grant
The Lin Lab received an award from the CHOP Omics Maximizing Grant (OMG) Fund. This 2-year, $100,000 award was designed to stimulate research in the cutting-edge fields of genomics, other omics, and big data, with the goal of developing new omics-based discoveries, diagnostics, and therapeutics for children. Dr. Lin will use the funding to develop an RNA-guided diagnostic technology for primary mitochondrial diseases (PMDs), using the efficient and cost-effective TEQUILA-seq method for targeted long-read RNA sequencing of PMD genes.
Nicole DeBruyne Joins the Lin Lab as a PhD Student
The Lin Lab is delighted to announce that Nicole DeBruyne, a Genetics & Epigenetics PhD student in Penn’s Cell & Molecular Biology (CAMB) program, has selected the Lin Lab for her thesis home. Nicole is interested in utilizing various sequencing technologies and cell-based assays to understand the genetics of human disease. Welcome, Nicole!
Lin Lab Receives 2022 Omics Maximizing Grant (OMG)
The Lin Lab received an award from the CHOP Omics Maximizing Grant (OMG) Fund. This 2-year, $100,000 award was designed to stimulate research in the cutting-edge fields of genomics, other omics, and big data, with the goal of developing new omics-based discoveries, diagnostics, and therapeutics for children. Dr. Lin will use the funding to develop an RNA-guided diagnostic technology for congenital disorders of glycosylation (CDGs), using the efficient and cost-effective TEQUILA-seq method for targeted long-read RNA sequencing of CDG genes.
Isabelle Heifetz Ament Joins the Lin Lab as a PhD Student
The Lin Lab is delighted to announce that Isabelle Heifetz Ament, a PhD student in the Biology Graduate Group at the University of Pennsylvania, has joined the lab to complete her thesis research. Isabelle will be studying the role of endogenous retroviruses (ERVs) in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Welcome, Isabelle!
Lin Lab Receives Award from CHOP Diagnostic Innovation Fund
The Lin Lab received an award from the CHOP Pathology Diagnostic Innovation Fund. This 1-year, $100,000 award was designed to accelerate development of new diagnostic tests, with the overall goal of encouraging translation of promising bench research to clinical tests. Dr. Lin will use the funding to develop an RNA-guided diagnostic technology for inborn errors of immunity (IEI), using the efficient and cost-effective TEQUILA-seq method for targeted long-read RNA sequencing of IEI genes.
Dr. Lan Lin Awarded CGTC Seed Grant
The Lin lab was awarded a CHOP Cell & Gene Therapy Collaborative (CGCT) Seed Grant. CHOP Seed Grants are intended to promote early-stage development of new ideas, with the goal of achieving preclinical proof-of-concept by the end of the 2-year grant period. Dr. Lin will use the funding to further develop her lab’s microfluidic single-cell TCR screen, which is designed to develop novel therapies for pediatric AML.
Dr. Lin Awarded Prestigious Grant from W.W. Smith Charitable Trust
Dr. Lan Lin was awarded a Medical Research Grant from the W.W. Smith Charitable Trust. The Grant provides 1 year of funding for basic research projects with high potential for direct impact in the fight against heart disease, cancer, and AIDS. Dr. Lin will use the funding to develop a novel microfluidic single-cell T-cell receptor (TCR) screen for pediatric acute myeloid leukemia (AML).
Noah Smith Joins the Lin Lab as a Research Technician
Noah Smith joined the Lin Lab after leaving a position at Johns Hopkins University. Noah is interested in third-generation/long-read sequencing technologies. Welcome, Noah!
Dr. Lan Lin Awarded Pilot Grant from the Frontiers in CDG Consortium
Dr. Lan Lin was awarded a Pilot and Feasibility Grant of $40,000 from the Frontiers in Congenital Disorders of Glycosylation (CDG) Consortium. The Grant provides 12 months of funding for “High Risk, High Reward” projects in CDG. Dr. Lin’s project will study the potential role of endogenously N-glycosylated RNA (glycoRNA) in samples from pediatric patients with CDG.
Nick Galambos Accepted to the University of Pennsylvania
Our Research Technician, Nick Galambos, was accepted into his first-choice PhD program in Cell & Molecular Biology at the University of Pennsylvania. Congratulations, Nick!
Welcome, Baby Alex!
Dr. Lan Lin gave birth to her second child, a healthy baby boy named Alex, on December 12th.
Dr. Siwei Luo Joins the Lin Lab as a Postdoctoral Fellow
The Lin Lab gained a new postdoctoral fellow, Dr. Siwei Luo. Siwei received his BS and PhD from the University of Science and Technology of China (USTC). He is interested in using interdisciplinary methods to study complex biological systems, especially biomacromolecular interactomes. His current research focuses on developing microfluidic technology to study single-cell RNA-protein interactions. Welcome, Siwei!
Nick Galambos Joins the Lin Lab as Research Technician
Nick Galambos joined the Lin Lab after leaving a Lab Coordinator position at Delaware County College. Nick hopes to gain research experience in the lab and plans to apply to graduate school in the future. Welcome, Nick!
Scientific Writer, Dr. Kate Kadash-Edmondson, Joins the Lin Lab
Dr. Kate Kadash-Edmonson joined the Lin Lab after 18 months in the biotech industry and over a decade working as a scientific writing consultant. She received her Bioengineering PhD from the University of Pennsylvania and completed a postdoc in Biochemistry & Molecular Biophysics. Kate will help mentor trainees and provide scientific writing support for the Lin Lab. Welcome, Kate!